Beilstein J. Org. Chem.2005,1, No. 9, doi:10.1186/1860-5397-1-9
-chloroindolizines readily underwent nucleophilic substitution at position 5 leading in high yields to novel 5-functionalised indolizines.
Keywords: 5-chloroindolizine; 5-substitutedindolizines; 5-indolizinone; nucleophilic substitution; Indolizines are an important class of heterocyclic compounds since many
natural alkaloids contain in their structure a saturated (swainsonine) or aromatic (camptothecin) indolizine moiety. While the chemistry of indolizines has been widely investigated[1] the chemistry of 5-substitutedindolizines remains very poor because there are only a few reliable ways for their
products in good yields.[3] An interesting method for preparing 5-substitutied indolizines by recyclization of oxazolo[3,2-a]pyridinium salts was developed in our laboratory.[4][5] Using this strategy a series of 5-substitutedindolizines have been prepared in good yields, but (although the method seems to
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Graphical Abstract
Scheme 1:
Synthesis of 2-aryl-5-chloro-6-cyano-7-methylindolizines 2. Possible tautomeric structures A and B ...